The Cracking Cancer Podcast

What Is The Pharmaceutical Industry? Episode 32.

In this revealing episode of "Cracking Cancer," host Dr. Kyle Concannon and co-host Samantha Murrell are joined by Kerry Wentworth, Chief Regulatory Officer at Nuvation Bio, to pull back the curtain on the pharmaceutical and biotech industry. Kerry, a veteran in the field, addresses the common perception that pharmaceutical companies are driven purely by financial metrics, stating that the primary mission is, in fact, patient-centered—to bring healthier, longer living to people.
The conversation dives deep into the high-risk reality of drug development. Kerry explains why drugs cost billions: the price must account for the staggering 90% failure rate of investigational new drugs, extensive animal and human trials, and complex manufacturing. They demystify the clinical trial process, clarifying the phases, the rigorous site selection process, and dispelling the myth that physicians receive financial kickbacks for enrolling patients. This episode is a must-listen for anyone who wants an honest, science-driven understanding of the dedication, cost, and high-stakes nature of the work required to bring a new cancer therapy to market.
Key Takeaways
Mission is Patient-Driven, Not Just Financial
Why Drugs Cost Billions
The Clinical Trial Timeline
Dispelling the Kickback Myth
The Future is Chronic Care
 
Chapters
(00:00) Understanding the Pharmaceutical Industry
(08:08) The Role of a Chief Regulatory Officer
(11:55) The Drug Development Process
(17:19) Clinical Trials: Design and Execution
(26:10) Phase One Trials and FDA Approval
(35:15) Understanding Investigator Payments
(42:16) Challenges in Cancer Vaccine Development
(49:41) Mistrust in Pharmaceutical Companies
(59:08) New Developments at Nueva Bio
 
The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org
 
Attributions
The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License
 
X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X
IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos
 

What Is Testicular Cancer? Episode 31.

Testicular cancer is the most common form of cancer in men aged 15-35, but nobody is talking about it! Until today that is.
In this crucial episode of "Cracking Cancer," host Dr. Kyle Concannon is joined by Dr. Andrew Johns, a GU Cancer specialist from MD Anderson Cancer Center, and Jon Fox, a testicular cancer survivor. They tackle the vital topic of testicular cancer, shedding light on its biology, treatment, and remarkably high survival rates.
Dr. Johns explains that the majority of cases are germ cell tumors and breaks down the staging and risk stratification (favorable, intermediate, and unfavorable), emphasizing that even with metastatic disease, long-term survival can be over 90% for favorable-risk cases. Guest Jon provides a raw, first-hand account of his fast-paced diagnosis—from noticing subtle pain to dealing with the ambiguity of his aggressive tumor subtype (Embryonal Carcinoma) and the resulting discrepancy in treatment recommendations (3 vs. 4 cycles of BEP chemotherapy). They discuss the standard workup, the significance of tumor markers, and the rigorous recovery required after major surgeries like the RPLND. This is essential listening for young men, their families, and anyone seeking clarity on a highly treatable yet highly aggressive disease.
Key Takeaways
Testicular Cancer is a Young Man's Disease
Early Symptoms & Workup
High Cure Rates, Even When Metastatic
Complex Treatment Decisions
Screening and Long-Term Monitoring
 
Chapters
(00:00) Understanding Testicular Cancer
(02:30) Signs and Symptoms of Testicular Cancer
(04:07) John's Personal Experience with Testicular Cancer
(07:22) Diagnosis and Initial Reactions
(17:49) The Role of Tumor Markers
(35:20) Understanding Testicular Cancer Survival Rates
(43:31) The Importance of Accurate Staging
(49:14) Chemotherapy Experience and Side Effects
(53:43) Post-Chemotherapy Treatments and Surgery
(01:10:50) Advice for Testicular Cancer Patients
 
The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org
 
Attributions
The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License
 
X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X
IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos
 

What Are Antibody Drug Conjugates? Episode 30.

In this crucial episode of "Cracking Cancer," host Dr. Kyle Concannon and patient advocate Samantha Murrell delve into Antibody Drug Conjugates (ADCs), a revolutionary class of targeted therapy. Samantha, who was treated with an ADC for her HER2 non-small cell lung cancer, shares her real-time experience with the drug's potent effects and cumulative side effects.
Dr. Concannon explains the sophisticated engineering behind ADCs: an antibody (the "key") is chemically linked to a highly toxic chemotherapy payload (the "bomb"). The goal is to specifically target cancer cells, providing the power of chemotherapy with fewer systemic side effects. The discussion covers the mechanism of action, the risks of "on-target, off-tumor" effects (hitting healthy cells with the same target), and drug "leakage" into the bloodstream, which is responsible for common side effects like nausea, fatigue, and hair loss. 
This episode is a must-listen for anyone starting an ADC regimen, offering candid advice on managing side effects, the importance of open communication with your care team, and the power of patient support groups.
 
Key Takeaways:
What is an ADC?
Antibodies are the key to specificity.
Side effects are still a reality.
Cumulative toxicity may require a break.
ADCs are pioneering new treatments.
 
Chapters:
(00:00) Understanding Antibody Drug Conjugates (ADCs)
(05:19) Antibodies and Their Specificity
(12:21) Challenges and Side Effects of ADCs
(17:06) Managing Side Effects and Treatment Breaks
(31:16) Understanding Drug Half-Life
(39:02) Managing Side Effects and Toxicities
(48:35) Future of ADCs in Cancer Treatment
(55:55) Advice for Patients Starting ADCs
 
The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org
 
Attributions
The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License
 
X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X
IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos
 

What Is A Medical Oncologist. Episode 29.

In this essential episode of "Cracking Cancer," host Dr. Kyle Concannon, a physician scientist and medical oncologist, sits down with patient advocate Samantha Murrell to demystify the role of the medical oncologist and how they fit into a patient's care journey. They clarify the distinct but collaborative roles of medical, surgical, and radiation oncologists.
Dr. Concannon provides an honest, behind-the-scenes look at the high-stakes world of oncology, from the personal preparation required for a first patient meeting to the emotional toll of difficult end-of-treatment conversations. He discusses the inner workings of the Tumor Board, the realities of clinical trials (including the inherent biases), and the challenges providers face when patients pursue alternative therapies. This episode is crucial for any patient seeking clarity on who their providers are, what they do, and how to best advocate for their personalized care plan.
 
Key Takeaways:
The Three Primary Oncology Roles
The Medical Oncologist is not a Gatekeeper
The Purpose of a Tumor Board
Second Opinions are Encouraged
The Ethical Challenge of Alternative Therapies
 
Chapters:
(00:00) Introduction to Cracking Cancer
(03:43) Training Pathways for Oncology Specialists
(08:09) Patient Care and Oncologist Collaboration
(19:31) The Importance of Second Opinions
(27:31) Alternative Therapies and Supplements
(33:38) Understanding Tumor Boards
(39:26) The Role of Clinical Trials in Oncology
(53:23) Emotional Impact on Oncologists
 
The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org
 
Attributions
The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License
 
X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X
IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

What Is A Radiologist? Episode 28.

In this episode, Dr. Lauren Groner, a Cardiothoracic Radiologist and Health Services Researcher, demystifies the field of radiology and its critical, often unseen, role in oncology. Dr. Groner breaks down the differences between Diagnostic and Interventional Radiologists, explaining how the former interprets complex images (CT, MRI, PET, X-rays) to diagnose and stage disease, while the latter performs minimally invasive, image-guided treatments.
Dr. Groner offers a rare glimpse into the daily life of a diagnostic radiologist, detailing their extensive medical training and the highly specialized nature of their work. She explains how radiologists act as "little detectives," synthesizing imaging findings with a patient’s full clinical history to narrow down a diagnosis and guide treatment. The discussion also explores the future of the field, highlighting exciting advances in AI, rapid imaging technology, and opportunistic screening that are transforming patient care. 
 
Key Takeaways:
Diagnostic vs. Interventional Radiologists
Radiologists are Physicians
A Report is a Detective Story
The Power of Opportunistic Screening
Communicate with Your Radiologist
 
Chapters
(00:00) Introduction to Radiology
(04:40) Radiology Reports and Clinical Decision Making
(11:26) Radiology in the Post-COVID Era
(20:49) Interacting with Patients and Providers
(44:26) Challenges and Responsibilities in Radiology
(54:33) The Importance of Radiologists
 
Attributions
The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License
 
X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X
IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

The Challenges with New Cancer Technology. Episode 27.

In this timely episode of "Cracking Cancer," host Dr. Kyle Concannon, a physician scientist, speaks with patient advocate Ashley Holt about the challenges of navigating new, aggressive cancer surveillance technologies. Ashley, a survivor of Stage I non-small cell lung cancer with a ROS1 mutation, chose to go beyond the standard of care by incorporating the Signatera circulating tumor DNA (ctDNA) blood test into her post-lobectomy monitoring.
Ashley shares her intense, real-time experience after her third ctDNA test came back positive despite all her conventional CT scans and a follow-up PET scan being normal. This outcome catapulted her into an "evidence-free zone," a state of profound anxiety and confusion where she must make critical treatment decisions—such as whether to start a lifelong targeted therapy—without clear medical consensus or established guidelines.
The conversation explores the ethical and emotional trade-offs of aggressive surveillance: the benefit of detecting potential recurrence earlier versus the harm of provoking intense anxiety and forcing patients to choose a path with no definitive right answer. This is essential listening for any patient considering advanced monitoring or struggling to reconcile standard medical guidelines with the flood of new, but unvalidated, technologies.
 
Key Takeaways
The Unintended Consequences of Aggressive Surveillance
The ctDNA Challenge
Shared Decision-Making is Imperfect
"Standard of Care" is Often the Best Care
Ask the Right Questions Upfront
 
Chapters:
(00:00) Navigating Post-Surgery Surveillance
(05:23) The Emotional Impact of Positive Test Results
(13:08) The Role of Clinical Trials and Guidelines
(20:41) Balancing Surveillance and Quality of Life
(30:29) Navigating Mental Health Amidst Cancer Uncertainty
(36:10) The Importance of Genetic Testing
(47:30) Empowering Patients in Their Cancer Journey
(59:25) Final Thoughts and Advocacy
 
Attributions
The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License
 
X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X
IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

The Intersection of Faith and Cancer. Episode 26.

In this deeply personal episode of "Cracking Cancer," host Dr. Kyle Concannon and guest Sara Sandoval, a stage four metastatic breast cancer patient, explore the rarely discussed intersection of faith and a cancer diagnosis. Sara shares her journey of turning to her Catholic faith after her diagnosis, finding solace, strength, and a sense of control in an otherwise chaotic and frightening reality.
This conversation is not about religious doctrine but about the human experience of grappling with a life-altering illness. Sarah and Dr. Concannon discuss the difficult question of "why me?" and the emotional struggle of facing a disease that feels outside of one's control. 
This episode is a raw, honest, and moving exploration of how spirituality and faith can provide a powerful source of comfort and purpose, helping people not just survive, but truly live during their cancer journey.
 
Key Takeaways:
Faith as a Source of Control
The Power of Prayer
Spirituality Beyond the Church
Mindset is a Choice
Leveraging Suffering for Good
 
Chapters:
(00:00) Meet Sara Sandoval: A Stage Four Cancer Patient
(03:38) The Power of Prayer in Coping with Cancer
(25:59) Signs and Symbols: Finding Comfort in Faith
(30:23) Community Support in Religious Groups
(36:33) Faith and Coping with Cancer
(51:46) Belief in the Afterlife
(01:05:14) Conclusion and Final Thoughts
 
Attributions
The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License
 
X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X
IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

Making Sense of Scan Results with Dr. Lauren Groner and Heidi Onda. Episode 25.

Navigating a cancer diagnosis often means a barrage of medical terms and images that can be confusing and frightening. In this powerful episode of "Cracking Cancer," host Dr. Kyle Concannon sits down with guests Heidi Onda, a lung cancer survivor and founder of the White Ribbon Project, and Dr. Lauren Groner, a cardiothoracic radiologist, to demystify the world of medical scans.
Heidi shares her personal experience with "scanxiety"—the intense emotional toll of waiting for scan results—and offers practical coping mechanisms. Dr. Groner provides a rare, behind-the-scenes look into the radiologist's process, breaking down the different types of scans (CT, PET, MRI), explaining the terminology in a patient-friendly way, and revealing the human judgment behind every report. The discussion reveals why a patient's self-advocacy and a trusting relationship with their care team are crucial for navigating a healthcare system that, despite its best intentions, can be slow and overwhelming. This episode is a must-listen for anyone who wants to regain a sense of control and hope during their cancer journey by better understanding the tests that guide their care.
 
Key Takeaways
Understanding "Scanxiety"
Radiology is more than just a picture
The terminology in a report has meaning
Advocate for yourself
You're on the same team
 
Chapters:
(00:00) Introduction to Cracking Cancer
(02:37) The Importance of Scans in Oncology
(15:55) The Radiologist's Perspective
(20:26) Reading and Understanding Your Scan Report
(28:13) Common Terminology and Misconceptions
(37:49) Heidi's Personal Experience with Scans
(43:51) Understanding Radiology Reports
(01:04:18) The White Ribbon Project
(01:06:07) Lung Cancer Screening and Resources
 
The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org
 
Attributions
The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License
 
X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X
IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

What Are Taxane Chemotherapies? Episode 24.

In this episode of "Cracking Cancer,"  Sara Sandoval, a stage four triple-positive metastatic breast cancer patient, and Whitney Lewis, an oncology pharmacist, provide an intimate and transparent look at taxane chemotherapies, a class of drugs commonly used in many cancer treatments.
Sarah shares her personal experience, offering a patient's perspective on the physical and emotional realities of treatment, from the initial shock of diagnosis to her unique experience of feeling better almost immediately after starting chemotherapy. Whitney provides her expert insight, explaining the science behind how taxanes work, why they're so widely used, and the differences between various formulations like paclitaxel and docetaxel.
The conversation addresses common side effects like hair loss and neuropathy, and both guests offer invaluable advice on managing these challenges, from practical tips for finding wigs and using cold caps to the crucial importance of open communication with your care team. This episode is a powerful and empowering guide for anyone facing a cancer diagnosis, providing clarity and hope by revealing that with the right knowledge and mindset, you can live a full life, even during treatment.
 
Chapters:
(00:00) Introduction to Cracking Cancer
(04:33) Pharmacist's Perspective on Taxanes
(14:14) Dosing Regimens and Side Effects
(20:11) Sarah's Journey and Hair Loss
(34:19) Navigating Wig Options
(44:21) Medications to Manage Side Effects
(01:00:40) Managing Neuropathy
(01:08:56) Final Advice and Encouragement
 
The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org
 
Attributions
The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License
 
X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X
IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

What is Lung Cancer Screening? Episode 23.

Lung Cancer Screening: Why You Should Get Checked and the Hope That Follows In this episode of "Cracking Cancer," Dr. Kyle Concannon, and guests, Dr. Lauren Groner, and seven-year lung cancer survivor Heidi Onda, tackle a critical public health issue: lung cancer screening. They explore the current guidelines for who should be screened, the science behind the low-dose lung CT, and the significant barriers—from patient anxiety to provider education—that prevent more people from getting this life-saving test. Dr. Groner, a cardiothoracic radiologist, demystifies the screening process, addressing common fears about radiation and false positives. Heidi Onda, founder of the White Ribbon Project, shares her powerful personal story as a non-smoker diagnosed with late-stage lung cancer, highlighting the urgent need to change public perception and eliminate the stigma associated with the disease. The discussion reveals the dramatic progress in lung cancer treatment and how early detection is the single greatest tool for improving outcomes and achieving cures. This episode is an essential listen for anyone who has ever wondered about lung cancer risk, the importance of screening, and the powerful role of patient advocacy in driving medical change.   Key Takeaways Who is eligible for lung cancer screening? The low-dose lung CT is safe and effective. Changing the narrative is critical. Screening rates are alarmingly low. Don't be afraid not to get screened.   Chapters (00:00) Introduction to Cracking Cancer (00:22) Meet the Guests (03:05) Understanding Low Dose Lung CT Screening (07:23) Eligibility Criteria for Lung Cancer Screening (14:33) Barriers to Screening Adoption (30:06) Understanding Screening Statistics and Impact (40:46) Insurance Coverage and Cost Considerations (48:23) Future of Lung Cancer Screening (57:54) Final Advice and Closing Thoughts   
 
The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org
 
Attributions
The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License
 
X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X
IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos